Adipogenesis

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Adipogenesis

Adipogenesis (pronounced: ad-i-po-gen-e-sis) is the biological process by which preadipocytes mature into adipocytes or fat cells. The process is complex and involves a series of biochemical steps.

Etymology

The term "Adipogenesis" is derived from the Latin word "adipo" meaning fat and the Greek word "genesis" meaning origin or creation.

Process

Adipogenesis begins with the commitment of mesenchymal stem cells (MSCs) to the adipocyte lineage, forming preadipocytes. These preadipocytes then undergo a series of changes, including cell growth arrest, clonal expansion, and terminal differentiation, to become mature adipocytes. This process is regulated by a network of transcription factors, including PPARγ and C/EBPs, and is influenced by various hormones, growth factors, and cytokines.

Significance

Adipogenesis is a critical process in the body's energy homeostasis and is closely related to metabolic diseases such as obesity and type 2 diabetes. Understanding the mechanisms of adipogenesis can provide insights into the development of these diseases and potential therapeutic strategies.

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