Angiogenin
Angiogenin
Angiogenin (pronounced an-gee-oh-jen-in, /æn.dʒi.oʊ.'dʒɛn.ɪn/) is a type of protein that plays a crucial role in the process of angiogenesis, the formation of new blood vessels from pre-existing ones.
Etymology
The term "Angiogenin" is derived from the Greek words "angeion" meaning "vessel" and "genes" meaning "born of, produced by". It was first identified in 1985 as a tumor-derived protein with the ability to stimulate the growth of new blood vessels.
Function
Angiogenin is secreted by cells and binds to actin on the surface of endothelial cells. Once bound, it is internalized and translocated to the nucleus, where it stimulates ribosomal RNA (rRNA) production, a key component of ribosome biogenesis. This process is essential for cell proliferation and growth, which are necessary for angiogenesis.
Clinical Significance
Angiogenin has been implicated in a variety of diseases, including cancer, diabetic retinopathy, and age-related macular degeneration. It is also associated with Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease, and certain forms of dementia.
Related Terms
- Angiogenesis
- Protein
- Actin
- Endothelial cells
- Nucleus
- Ribosomal RNA
- Ribosome
- Cancer
- Diabetic retinopathy
- Age-related macular degeneration
- Amyotrophic lateral sclerosis
- Dementia
External links
- Medical encyclopedia article on Angiogenin
- Wikipedia's article - Angiogenin
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