Azosemide
Azosemide
Azosemide (pronounced as az-oh-sem-ide) is a potent loop diuretic used primarily in the treatment of congestive heart failure. It is also used to treat edema and hypertension.
Etymology
The term "Azosemide" is derived from the chemical structure of the drug, which contains an azo group (N=N) and a semicarbazide group.
Pharmacology
Azosemide is a loop diuretic that inhibits the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle, leading to a reduction in reabsorption of sodium and chloride ions, and increased urine output. This results in decreased fluid accumulation in the body, helping to alleviate symptoms of congestive heart failure and edema.
Related Terms
- Loop diuretic: A class of diuretics that act on the ascending loop of Henle in the kidney.
- Congestive heart failure: A chronic condition in which the heart doesn't pump blood as well as it should.
- Edema: A condition characterized by an excess of watery fluid collecting in the cavities or tissues of the body.
- Hypertension: Also known as high blood pressure, it is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.
Side Effects
Like other loop diuretics, azosemide can cause a number of side effects, including dehydration, hypokalemia (low potassium levels), hyponatremia (low sodium levels), and hypomagnesemia (low magnesium levels). It can also cause ototoxicity (ear damage), although this is rare.
See Also
External links
- Medical encyclopedia article on Azosemide
- Wikipedia's article - Azosemide
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