Bumetanide

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Bumetanide

Bumetanide (pronounced: byoo-MET-a-nide) is a potent diuretic medication used primarily to treat heart failure, liver disease, and kidney disease. It is a loop diuretic, meaning it works in the loop of Henle in the kidney to increase the excretion of sodium and water, thereby reducing fluid overload in the body.

Etymology

The term "Bumetanide" is derived from the chemical name butylmethanimidamide, indicating its chemical structure. The suffix "-ide" is commonly used in drug nomenclature to denote substances derived or extracted from a particular source.

Pharmacology

Bumetanide works by inhibiting the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle in the kidney. This inhibition prevents the reabsorption of sodium, potassium, and chloride ions, leading to an increase in urine output (diuresis). This helps to reduce fluid overload in conditions such as heart failure, liver disease, and kidney disease.

Related Terms

  • Diuretic: A class of drugs that increase the excretion of water and salts in the urine.
  • Heart Failure: A condition in which the heart is unable to pump enough blood to meet the body's needs.
  • Liver Disease: A broad term for various diseases that affect the function of the liver.
  • Kidney Disease: A condition in which the kidneys are unable to function properly.
  • Sodium-Potassium-Chloride Cotransporter: A protein that aids in the reabsorption of sodium, potassium, and chloride ions in the kidney.

See Also

External links

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