Belotecan

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search


W8MD and WikiMD founder

Editor-In-Chief: Prab R. Tumpati M.D.. Founder, WikiMD and W8MD Weight Loss, Sleep and MedSpa Centers. Dr. Tumpati is board certified physician practicing sleep medicine, obesity medicine, aesthetic medicine and internal medicine. Dr. Tumpati’s passion is prevention rather than cure. As a physician with fellowship training in Obesity Medicine, Dr. Tumpati has a unique approach to wellness, weight loss, aesthetics with a focus on prevention rather than cure. Dr. Tumpati believes in educating the public on the true science and art of medicine, nutrition, wellness and beauty.

WikiMD Resources for Belotecan
Articles
Most recent articles on Belotecan

Most cited articles on Belotecan Review articles on Belotecan

Articles on Belotecan in N Eng J Med, Lancet, BMJ

Media
Powerpoint slides on Belotecan

Images of Belotecan Photos of Belotecan

Podcasts & MP3s on Belotecan Videos on Belotecan

Evidence Based Medicine
Cochrane Collaboration on Belotecan

Bandolier on Belotecan TRIP on Belotecan

Clinical Trials
Ongoing Trials on Belotecan at Clinical Trials.gov

Trial results on Belotecan Clinical Trials on Belotecan at Google

Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Belotecan

NICE Guidance on Belotecan NHS PRODIGY Guidance

FDA on Belotecan CDC on Belotecan

Books
Books on Belotecan
News
Belotecan in the news

Be alerted to news on Belotecan News trends on Belotecan

Commentary
Blogs on Belotecan
Definitions
Definitions of Belotecan
Patient Resources / Community
Patient resources on Belotecan

Discussion groups on Belotecan Patient Handouts on Belotecan

Directions to Hospitals Treating Belotecan Risk calculators and risk factors for Belotecan

Healthcare Provider Resources
Symptoms of Belotecan

Causes & Risk Factors for Belotecan Diagnostic studies for Belotecan

Treatment of Belotecan

Continuing Medical Education (CME)
CME Programs on Belotecan
International / other languages

en Espanol en Francais

Business
Belotecan in the Marketplace

Patents on Belotecan

Experimental / Informatics
List of terms related to Belotecan
Belotecan
Belotecan.svg
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
E number{{#property:P628}}
CompTox Dashboard (EPA)
  • {{#property:P3117}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC25H27N3O4
Molar mass433.50 g/mol g·mol−1
3D model (JSmol)
  (verify)

Belotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue indicated for Small Cell Lung Cancer and Ovarian Cancer, approved in South Korea under the trade name Camtobell(R), presented in 2 mg vials for injection.[1] The drug is marketed by ChongKunDang Pharmaceuticals [2] since 2003 [3]

Belotecan blocks topoisomerase I with a pIC50 of 6.56,[4] stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.

References


Latest research - Belotecan

PubMed
Clinical trials
 

Belotecan is part of WikiMD's free ^articles!

^Belotecan (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available