Beta-Hydroxy beta-methylbutyric acid

β-Hydroxy β-methylbutyric acid (HMB)

Overview

File:HMB-Synthese.svg

Infographic illustrating the chemical structure of β-Hydroxy β-methylbutyric acid (HMB).

β-Hydroxy β-methylbutyric acid (HMB), also known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans. It plays a significant role in muscle health and is used both as a dietary supplement and as an ingredient in certain medical foods.

Role in the Body

HMB is involved in the synthesis of muscle tissue and has been shown to reduce muscle breakdown. It is a metabolite of the essential amino acid Leucine, which is known for its role in protein synthesis and muscle repair.

Medical and Dietary Uses

HMB supplements in capsule form.

HMB supplements are used to promote wound healing and provide nutritional support for people with muscle wasting due to conditions like Cancer or HIV/AIDS. It is particularly beneficial for preserving muscle mass in individuals who are immobilized or undergoing periods of muscle disuse.

Benefits in Exercise and Recovery

In healthy adults, supplementation with HMB has been shown to:

• Increase exercise-induced gains in muscle size, muscle strength, and lean body mass.
• Reduce skeletal muscle damage from exercise.
• Improve aerobic exercise performance.
• Expedite recovery from exercise.

Research and Reviews

Medical reviews and meta-analyses indicate that HMB supplementation helps to preserve or increase lean body mass and muscle strength in individuals experiencing age-related muscle loss or other conditions leading to muscle atrophy.

Safety and Dosage

The safety profile of HMB supplementation is generally considered good, but as with any supplement, it should be used under the guidance of a healthcare professional.