Brexanolone
Brexanolone
Brexanolone (pronounced as brex-an-oh-lone) is a steroid medication used for the treatment of postpartum depression in adult women. It is sold under the brand name Zulresso.
Etymology
The name "Brexanolone" is derived from its chemical structure, which is a synthetic form of the naturally occurring hormone allopregnanolone. The prefix "Brex" is arbitrary and does not have a specific meaning.
Usage
Brexanolone is used to treat postpartum depression in adult women. It is administered as a continuous intravenous infusion over a total of 60 hours (2.5 days) under the supervision of a healthcare provider in a certified healthcare facility.
Mechanism of Action
Brexanolone works by modulating the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. It binds to synaptic and extrasynaptic GABA-A receptors, increasing the inhibitory effects of GABA on neuronal excitability.
Side Effects
Common side effects of Brexanolone include sleepiness, dry mouth, loss of consciousness and flushing. Serious side effects may include suicidal thoughts, abnormal heart rhythms, and allergic reactions.
Related Terms
External links
- Medical encyclopedia article on Brexanolone
- Wikipedia's article - Brexanolone
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