C-Jun

C-Jun (pronounced see-jun) is a protein that in humans is encoded by the JUN gene. It is a component of the transcription factor complex AP-1 and has a central role in cell proliferation, apoptosis, and oncogenesis.

Etymology

The name C-Jun is derived from the Japanese word jun, which means "pure". The "C" in C-Jun stands for "cellular", distinguishing it from its viral counterpart, v-Jun.

Function

C-Jun forms a dimer with c-Fos in order to create the transcription factor complex AP-1. This complex binds to DNA and regulates gene expression, which in turn controls processes such as cell proliferation and apoptosis.

Related Terms

• Transcription factor
• AP-1
• Cell proliferation
• Apoptosis
• Oncogenesis
• c-Fos
• DNA

See Also

• Gene
• Protein
• Japanese language

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