CACNA2D3

CACNA2D3 is a gene that encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex in humans. This complex plays a crucial role in the release of neurotransmitters from neurons and from a variety of non-neuronal cells. This particular subunit can dramatically alter the kinetics of the calcium channel and plays a key role in its activation and inactivation.

Function

The CACNA2D3 gene is part of the CACNA2D gene family. It encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

Clinical Significance

Mutations in the CACNA2D3 gene have been associated with various types of cancer, including breast cancer, lung cancer, and gastric cancer. The gene is also thought to play a role in neuropathic pain and epilepsy.

Research

Research into the CACNA2D3 gene is ongoing, with scientists seeking to better understand its function and the role it plays in disease. This research could potentially lead to new treatments for a variety of conditions.

See Also

• CACNA2D1
• CACNA2D2
• CACNA2D4

References

   This article is a medical stub. You can help WikiMD by expanding it!