CCBP2

CCBP2 or Chemokine Binding Protein 2 is a protein that in humans is encoded by the CCBP2 gene. It is also known as ChemR23 or Chemokine Receptor 23.

Function

CCBP2 is a receptor for the Chemokine Chemerin. It is expressed in various tissues such as the spleen, liver, and testis. The protein is believed to play a role in the immune system, specifically in the migration of white blood cells to sites of inflammation.

Gene

The CCBP2 gene is located on the chromosome 12 (12q13.2-q13.3) and spans approximately 20 kb. The gene contains two exons and one intron.

Clinical significance

Mutations in the CCBP2 gene have been associated with Wharton's jelly and umbilical cord abnormalities. Further research is needed to fully understand the implications of these mutations.

See also

• Chemokine receptor
• Chemokine
• Chemerin

External links

• NCBI Gene
• UniProt