Chemerin

Chemerin is a protein that in humans is encoded by the RARRES2 gene. It is a chemoattractant protein that is known to play a role in immune response, adipogenesis, and angiogenesis.

Function

Chemerin is a chemoattractant protein that is secreted as an inactive precursor (prochemerin) and is activated by the removal of six amino acids from its C-terminus. This activation is carried out by proteases that are present in inflammation and coagulation, such as elastase and plasmin. Once activated, chemerin binds to the chemokine like receptor 1 (CMKLR1), which is expressed on various immune cells, including macrophages, dendritic cells, and natural killer cells. This binding leads to the activation of these cells and their migration to the site of inflammation.

Clinical significance

Chemerin has been implicated in a number of diseases, including obesity, diabetes, and cardiovascular disease. It is also involved in the regulation of inflammation and immune response, and has been shown to play a role in the progression of certain types of cancer.

External links

• NCBI Gene

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