CD44

CD44

CD44 (pronounced "C-D forty-four") is a cell surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is also known as Hermes antigen and Hyaluronate receptor.

Pronunciation

CD44 is pronounced as "C-D forty-four".

Etymology

The term "CD44" is derived from the term "Cluster of Differentiation 44". The Cluster of Differentiation (CD) terminology was established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens in 1982, where a system was proposed to classify monoclonal antibodies (mAbs) against leukocyte surface antigens.

Function

CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is closely related to its glycosylation state. CD44 influences a variety of cellular functions, including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis.

Related Terms

• Cell Adhesion
• Glycoprotein
• Hermes Antigen
• Hyaluronic Acid
• Hyaluronate Receptor
• Lymphocyte Activation
• Matrix Metalloproteinases
• Osteopontin
• Tumor Metastasis

External links

• Medical encyclopedia article on CD44
• Wikipedia's article - CD44

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