CEACAM6

CEACAM6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6) is a glycoprotein that is encoded by the CEACAM6 gene in humans. It is a member of the carcinoembryonic antigen (CEA) gene family.

Function

CEACAM6 is a cell surface receptor that plays a role in cell adhesion and in intracellular signaling. It is involved in various cellular processes such as apoptosis, cell proliferation, and differentiation. It is also implicated in cancer as it is overexpressed in certain types of cancer, including pancreatic cancer, colorectal cancer, and non-small cell lung cancer.

Structure

The CEACAM6 protein is a type II transmembrane glycoprotein. It consists of an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain contains three immunoglobulin-like domains, which are involved in cell adhesion.

Clinical significance

Overexpression of CEACAM6 has been associated with various types of cancer. It has been suggested as a potential biomarker for the detection and prognosis of certain cancers. In addition, it has been proposed as a target for cancer therapy.

See also

• Carcinoembryonic antigen
• Cell adhesion
• Glycoprotein
• Biomarker

References

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