Cinitapride

Cinitapride is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in Spain and Mexico. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.

Mechanism of action

Cinitapride has a dual mechanism of action. It works as an agonist of the 5-HT1 and 5-HT4 receptors, and as an antagonist of the 5-HT2 receptors. This dual action makes it effective in treating certain gastrointestinal conditions.

Uses

Cinitapride is used in the treatment of gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and as a prokinetic agent in conditions such as gastroparesis and functional dyspepsia.

Side effects

The most common side effects of cinitapride include dizziness, headache, diarrhea, and abdominal pain. In rare cases, it can cause extrapyramidal symptoms.

Contraindications

Cinitapride is contraindicated in patients with known hypersensitivity to the drug, and in those with gastrointestinal hemorrhage, mechanical obstruction, or perforation.

Interactions

Cinitapride may interact with other drugs such as anticholinergic medications, antipsychotic drugs, and antiarrhythmic drugs.

Pharmacokinetics

Cinitapride is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. It is excreted primarily in the urine.

See also

• Gastroprokinetic agent
• 5-HT receptor
• Benzamide

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  Cinitapride chemical structure

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  3D model of Cinitapride

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  Cinitapride synthesis pathway