Darodipine

Darodipine (also known as PY 108-068) is a calcium channel blocker that is used in the treatment of hypertension. It is a dihydropyridine derivative and is similar to other calcium channel blockers such as amlodipine, felodipine, and isradipine.

Pharmacology

Darodipine inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle. It binds to dihydropyridine and phenylalkylamine binding sites. The binding is voltage-dependent and is enhanced at depolarized membrane potentials.

Clinical Use

Darodipine is used in the treatment of hypertension. It lowers blood pressure by relaxing the smooth muscle in the walls of the arteries, causing them to open wider. This reduces the pressure in the arteries, making it easier for the heart to pump blood.

Side Effects

Like other calcium channel blockers, darodipine can cause a number of side effects. These can include dizziness, flushing, headache, nausea, palpitations, and edema. In rare cases, it can cause serious side effects such as arrhythmia and hypotension.

References

External Links

Darodipine on Drugs.com
Darodipine on PubChem

Darodipine structure

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