Dihydrouridine
Dihydrouridine
Chemical structure of dihydrouridine
Dihydrouridine (DHU) is a modified nucleoside found in the RNA molecules of various organisms. It is formed by the reduction of the uridine nucleoside, resulting in the addition of two hydrogen atoms to the uracil ring. This modification plays a crucial role in the structure and function of RNA.
Structure
Dihydrouridine is composed of a uracil base attached to a ribose sugar through a β-N-glycosidic bond. The reduction of uridine leads to the formation of a dihydro derivative, where the C5-C6 double bond of uracil is saturated with two hydrogen atoms. This modification results in the formation of a dihydropyrimidine ring.
Function
Dihydrouridine is commonly found in the tRNA (transfer RNA) molecules of many organisms. It is believed to play a role in stabilizing the tRNA structure and enhancing its functionality. The presence of dihydrouridine in tRNA has been associated with increased thermal stability and resistance to chemical degradation.
Furthermore, dihydrouridine has been implicated in the recognition and binding of specific amino acids during protein synthesis. It is thought to contribute to the accuracy and efficiency of the translation process by facilitating the proper pairing of tRNA with the corresponding codons on the mRNA (messenger RNA) template.
Importance
The presence of dihydrouridine in tRNA is highly conserved across different species, indicating its evolutionary significance. It is believed to have originated early in the evolution of life and has been maintained due to its functional advantages.
Dihydrouridine is also used as a marker for the identification and characterization of tRNA molecules. Its presence can be detected through various biochemical and molecular biology techniques, allowing researchers to study the diversity and abundance of tRNA in different biological systems.
References
See also
This RNA related article is a stub. You can help WikiMD by expanding it.
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
