Disodium aurothiomalate
Disodium aurothiomalate (also known as gold sodium thiomalate) is a gold compound that has been used for its immunomodulatory effects in the treatment of rheumatoid arthritis. It is classified as a disease-modifying antirheumatic drug (DMARD) and is also used in the treatment of other autoimmune diseases.
History
Disodium aurothiomalate was first used in the treatment of rheumatoid arthritis in the 1930s. Its use has declined in recent years due to the development of newer DMARDs with fewer side effects.
Mechanism of Action
The exact mechanism of action of disodium aurothiomalate is not fully understood. It is believed to inhibit the activity of lymphocytes and macrophages, key cells in the immune response that are overactive in autoimmune diseases.
Side Effects
Common side effects of disodium aurothiomalate include skin rash, mouth ulcers, and diarrhea. More serious side effects can include kidney damage and blood disorders.
Contraindications
Disodium aurothiomalate is contraindicated in patients with a known allergy to gold compounds. It should also be used with caution in patients with kidney disease or blood disorders.
See Also
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Contributors: Prab R. Tumpati, MD
