EML4

EML4 (Echinoderm Microtubule-associated protein-Like 4) is a protein that in humans is encoded by the EML4 gene. It is a member of the echinoderm microtubule-associated protein (EMAP) family and plays a crucial role in microtubule formation, which is an essential process for cell division and cell cycle progression.

Function

EML4 is involved in the formation of microtubules, a component of the cell's cytoskeleton. Microtubules are involved in a wide variety of cellular activities, including mitosis, intracellular transport, and the maintenance of cell shape. EML4 is believed to assist in stabilizing microtubules and promoting their assembly.

Clinical significance

EML4 has been implicated in a variety of human diseases, most notably lung cancer. A specific gene fusion between EML4 and the anaplastic lymphoma kinase (ALK) gene has been identified in a subset of non-small cell lung cancers. This EML4-ALK fusion gene is believed to drive the growth of cancer cells and is a target for specific therapies.

See also

• Microtubule
• Cell cycle
• Lung cancer
• Anaplastic lymphoma kinase

External links

• GeneCards - EML4