Estradiol benzoate/estradiol phenylpropionate

Estradiol benzoate/estradiol phenylpropionate (EB/EP) is a combination drug that contains estradiol benzoate and estradiol phenylpropionate, two forms of the primary female sex hormone estrogen. It is used in hormone therapy for menopausal symptoms and hypogonadism in women, and in hormone therapy for transgender women.

Etymology

The term "estradiol" is derived from estra-, which is a contraction of "oestrus" (Latin for "frenzy" or "heat"), and -diol, a chemical term and suffix indicating that the compound contains two alcohol groups. The term "benzoate" refers to the benzoic acid from which it is derived, and "phenylpropionate" refers to the phenylpropanoic acid from which it is derived.

Pharmacology

EB/EP is a prodrug of estradiol, meaning it is metabolized in the body into estradiol. It is administered via intramuscular injection, and has a longer duration of action than estradiol itself due to the slow release of estradiol from the muscle into the bloodstream.

Uses

EB/EP is used in hormone therapy for menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis. It is also used in hormone therapy for hypogonadism in women, a condition in which the body does not produce enough sex hormones. In addition, it is used in hormone therapy for transgender women, to help them develop secondary sexual characteristics more typical of women.

Side effects

Like all medications, EB/EP can have side effects. These can include breast tenderness, nausea, headache, and mood changes. More serious side effects can include blood clots, stroke, and certain types of cancer.

See also

• Estradiol
• Estrogen
• Hormone therapy
• Menopause
• Hypogonadism
• Transgender hormone therapy

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