Fibrate
Fibrate
Fibrate (/faɪˈbreɪt/), also known as fibrates, is a class of medication primarily prescribed to decrease high levels of cholesterol in the blood, particularly triglycerides.
Etymology
The term "fibrate" is derived from the chemical structure of these drugs, which are fibric acid derivatives.
Usage
Fibrates are used in the treatment of hyperlipidemia, a condition characterized by abnormally elevated levels of any or all lipids or lipoproteins in the blood. They are also used to treat dyslipidemia, where there is an abnormal amount of lipids (e.g., cholesterol and/or fat) in the blood.
Mechanism of Action
Fibrates work by activating the peroxisome proliferator-activated receptor alpha (PPARα), a receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation.
Related Terms
- Hyperlipidemia: A condition in which there are high levels of fat particles (lipids) in the blood.
- Dyslipidemia: An abnormal amount of lipids (e.g., cholesterol and/or fat) in the blood.
- Peroxisome proliferator-activated receptor alpha (PPARα): A receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation.
- Lipids: Organic compounds that are fatty acids or their derivatives and are insoluble in water but soluble in organic solvents.
- Cholesterol: A type of fat found in your blood. Your liver makes cholesterol for your body.
External links
- Medical encyclopedia article on Fibrate
- Wikipedia's article - Fibrate
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