GLI1
GLI1 is a protein that in humans is encoded by the GLI1 gene. It is a member of the C2H2-type zinc finger protein subclass of the Gli family. GLI1 is a key mediator of the Sonic hedgehog signaling pathway and has been implicated in the development and progression of several human cancers.
Function
GLI1 functions as a transcriptional activator that binds to the 5' flanking region of target genes. The role of this protein in embryonic development and tumorigenesis has been extensively studied. It is involved in the processes of cell growth, survival, and the development of various tissues and organs.
Clinical significance
Alterations in the GLI1 gene have been associated with several types of cancer, including basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma. In these cancers, GLI1 is often overexpressed, leading to increased cell proliferation and survival. Inhibitors of GLI1 are currently being investigated as potential cancer therapeutics.
See also
References
External links
- GLI1 at the US National Library of Medicine Medical Subject Headings (MeSH)
| Tumor suppressor genes and Oncogenes | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| Zinc finger proteins | ||||||||
|---|---|---|---|---|---|---|---|---|
This zinc finger proteins related article is a stub.
|
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
