GcMAF

GcMAF (Gc Protein-derived Macrophage Activating Factor) is a protein produced by modification of vitamin D-binding protein. Biochemically, GcMAF results from sequential deglycosylation of the vitamin D-binding protein (the Gc protein), which is naturally promoted by lymphocytes (B and T cells).

Biochemistry

The native Gc protein (also known as vitamin D3-binding protein) is a glycoprotein that contains a single sugar chain moiety. The sugar moiety of the native Gc protein is composed of three sugars, galactose, N-acetylgalactosamine, and sialic acid, the latter of which is critical for the conversion of Gc protein to GcMAF.

Function

GcMAF is a potent stimulator of the immune system. It plays a role in the activation of macrophages, a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, and cancer cells in a process called phagocytosis.

Clinical Significance

GcMAF has been studied for its potential use in the treatment of various diseases, including cancer, HIV, and autism. However, the scientific evidence supporting these uses is currently limited and further research is needed.

Controversy

The use of GcMAF has been controversial due to lack of robust clinical evidence and regulatory issues. In some countries, GcMAF products have been banned due to safety concerns.

See Also

• Macrophage
• Vitamin D-binding protein
• Immunotherapy

External Links

• GcMAF.eu

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