IRF8
IRF8
IRF8 (Interferon Regulatory Factor 8), pronounced as /ˌaɪˌɑːrˈeɪt/, is a transcription factor that plays a crucial role in the immune system. The term "IRF8" is derived from the words "Interferon Regulatory Factor" and the number "8", indicating its position in the series of identified IRFs.
Function
IRF8 is a member of the interferon regulatory factor (IRF) family of transcription factors, which are characterized by a unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes.
Clinical Significance
Mutations in the IRF8 gene are associated with the autosomal recessive immunodeficiency condition known as IRF8 deficiency. This condition is characterized by a lack of immune response to mycobacterial infections, leading to severe health complications.
Related Terms
See Also
External links
- Medical encyclopedia article on IRF8
- Wikipedia's article - IRF8
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