Inner cell mass

Inner Cell Mass (ICM) is a distinct group of cells found in the early development stage of mammals, specifically in the blastocyst. The ICM eventually forms the embryo.

Overview

The blastocyst stage of mammalian development is characterized by a fluid-filled cavity surrounded by a layer of cells known as the trophoblast. Within this structure, a small cluster of cells known as the Inner Cell Mass (ICM) is found. These cells are pluripotent, meaning they have the potential to differentiate into any cell type in the body.

Development

The ICM forms during the blastocyst stage of development, which occurs approximately five days after fertilization in humans. The cells of the ICM are derived from the morula, a solid ball of cells that forms after several rounds of cell division following fertilization.

Function

The cells of the ICM are pluripotent, meaning they have the potential to differentiate into any cell type in the body. This pluripotency is crucial for the formation of the various tissues and organs of the developing embryo.

Clinical Significance

The ICM is of particular interest in the field of regenerative medicine and stem cell research. These pluripotent cells can be used to generate embryonic stem cells, which have the potential to differentiate into any cell type in the body. This makes them a valuable tool for studying development, disease, and potential therapeutic applications.

See Also

• Blastocyst
• Trophoblast
• Morula
• Regenerative Medicine
• Stem Cell Research
• Embryonic Stem Cells

References

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  Diagram of Blastocyst Stage

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  ICM Signaling

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  Inner cell mass

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  Inner cell mass