Interleukin-11 receptor

Interleukin-11 receptor (IL-11R) is a type of protein that is encoded by the IL11RA gene in humans. It is a part of the interleukin receptor family, which plays a crucial role in the immune system and inflammatory response.

Structure

The IL-11R is a transmembrane protein that is primarily expressed on the surface of hematopoietic cells. It consists of two subunits: the alpha subunit (IL-11Rα) and the beta subunit (IL-11Rβ). The alpha subunit is specific to IL-11, while the beta subunit is shared with other cytokine receptors.

Function

The primary function of the IL-11R is to bind with interleukin-11 (IL-11), a cytokine that plays a key role in hematopoiesis and immune response. Upon binding with IL-11, the receptor activates the JAK/STAT signaling pathway, leading to the transcription of target genes that regulate cell growth, differentiation, and apoptosis.

Clinical Significance

Mutations in the IL11RA gene can lead to abnormalities in the IL-11R, which can result in various diseases. For instance, a deficiency in IL-11Rα has been associated with Craniosynostosis and dental anomalies. Moreover, overexpression of IL-11R has been observed in several types of cancer, including breast cancer and gastric cancer, suggesting a potential role in tumor progression.

Research

Research on IL-11R is ongoing, with studies focusing on its role in health and disease, as well as its potential as a therapeutic target. For example, IL-11R antagonists are being explored as potential treatments for conditions such as rheumatoid arthritis and cancer.

See Also

• Interleukin-11
• Interleukin receptor
• JAK/STAT signaling pathway

References

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