Karen Wetterhahn

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KarenWetterhahn

Karen Wetterhahn (October 16, 1948 – June 8, 1997) was an American professor of chemistry at Dartmouth College, New Hampshire, known for her research in heavy metal poisoning, particularly mercury and its compounds. Her work has had a significant impact on the fields of toxicology and occupational health, leading to enhanced safety protocols in laboratory safety and chemical handling. Tragically, Wetterhahn's own life was cut short by mercury poisoning, following an accident in her laboratory that exposed her to dimethylmercury, a highly toxic compound.

Early Life and Education

Karen Wetterhahn was born in Plattsburgh, New York, and developed an interest in science from an early age. She pursued her passion by attending St. Lawrence University, where she earned a bachelor's degree in chemistry. She furthered her education at Columbia University, obtaining a Ph.D. in chemistry. Her doctoral research focused on the mechanisms of metal ion interactions with nucleic acids, laying the groundwork for her future contributions to the field of metal toxicity.

Career

After completing her Ph.D., Wetterhahn joined the faculty at Dartmouth College, where she would spend the entirety of her academic career. She co-founded the college's Toxic Metals Research Program, aiming to investigate the effects of heavy metals on living organisms and the environment. Her research contributed significantly to understanding the molecular mechanisms by which heavy metals cause DNA damage and cell death, with a particular focus on mercury and cadmium.

Wetterhahn's work was instrumental in highlighting the dangers posed by certain forms of mercury, especially organic mercury compounds like dimethylmercury. These compounds are highly neurotoxic and can penetrate biological barriers, including the blood-brain barrier, leading to severe neurological damage.

Accident and Legacy

In 1996, Wetterhahn was conducting research on the toxic effects of heavy metal exposure. Despite following standard safety protocols and wearing protective gloves, she accidentally spilled a few drops of dimethylmercury on her hand. This incident led to her developing symptoms of mercury poisoning five months later, culminating in her death in June 1997.

Wetterhahn's tragic accident brought about a reevaluation of laboratory safety standards worldwide. It underscored the need for stricter safety measures when handling highly toxic substances and led to the development of new guidelines for the use of protective gear in research labs.

Her legacy includes the Karen Wetterhahn Award at Dartmouth College, established in her memory to recognize outstanding achievements in science research by undergraduate women.

Conclusion

Karen Wetterhahn's contributions to the field of chemistry, particularly in the study of toxic metals, have left a lasting impact on both science and safety in the laboratory. Her unfortunate death serves as a stark reminder of the risks associated with chemical research and the importance of rigorous safety protocols.

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