Lipoprotein lipase
Lipoprotein Lipase
Lipoprotein lipase (pronounced: li-po-PRO-teen LIE-pase), often abbreviated as LPL, is a crucial enzyme involved in lipid metabolism. It plays a significant role in the hydrolysis of triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into free fatty acids.
Etymology
The term "lipoprotein lipase" is derived from the Greek words 'lipos' meaning fat, 'proteios' meaning of the first quality, and 'lipase' meaning fat-splitting enzyme.
Function
Lipoprotein lipase is primarily produced by adipose tissue and muscle tissue. It is responsible for the breakdown of triglycerides, transforming them into free fatty acids and glycerol. These components are then used by the body for energy production or stored in adipose tissue for future use.
Related Terms
- Hyperlipoproteinemia: A condition characterized by elevated levels of lipoproteins in the blood.
- Apolipoprotein: A protein that binds lipids to form lipoproteins.
- Lipid metabolism: The process by which lipids are synthesized and degraded in cells.
Disorders
Deficiency or dysfunction of lipoprotein lipase can lead to disorders such as:
- Lipoprotein lipase deficiency: A rare genetic disorder characterized by a severe lack of lipoprotein lipase, leading to high triglyceride levels in the blood.
- Hyperlipoproteinemia type I: A disorder caused by defective lipoprotein lipase, resulting in elevated levels of chylomicrons and triglycerides in the blood.
See Also
External links
- Medical encyclopedia article on Lipoprotein lipase
- Wikipedia's article - Lipoprotein lipase
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