Mast cell leukemia

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Mast cell leukemia
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Fatigue, weight loss, fever, skin lesions, abdominal pain
Complications	Anemia, thrombocytopenia, hepatosplenomegaly, gastrointestinal bleeding
Onset	Typically in adulthood
Duration	Chronic
Types	N/A
Causes	Genetic mutations in mast cells
Risks	Unknown
Diagnosis	Bone marrow biopsy, blood test
Differential diagnosis	Systemic mastocytosis, acute myeloid leukemia
Prevention	N/A
Treatment	Chemotherapy, tyrosine kinase inhibitors, stem cell transplant
Medication	N/A
Prognosis	Poor
Frequency	Very rare
Deaths	N/A

Mast cell leukemia is a rare and aggressive subtype of systemic mastocytosis characterized by the proliferation of mast cells in the bone marrow and other organs. It is classified as a myeloproliferative neoplasm and is associated with a poor prognosis.

Signs and symptoms

Patients with mast cell leukemia often present with symptoms related to the infiltration of mast cells into various organs. These can include fatigue, weight loss, fever, and abdominal pain. In addition, the release of histamine and other mediators from mast cells can cause flushing, itching, diarrhea, and anaphylactic reactions.

Diagnosis

The diagnosis of mast cell leukemia is based on the presence of mast cells in the bone marrow and other tissues, as well as the presence of certain mutations in the KIT gene. Other diagnostic tests can include blood tests, bone marrow examination, and genetic testing.

Treatment

Treatment for mast cell leukemia is typically aggressive and can include chemotherapy, stem cell transplantation, and targeted therapies such as tyrosine kinase inhibitors.

Prognosis

The prognosis for mast cell leukemia is generally poor, with a median survival time of less than a year. However, some patients may respond well to treatment and achieve a longer survival time.

See also

• Mastocytosis
• Leukemia
• Myeloproliferative neoplasm

References

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