Melatonin receptor 1B

Melatonin receptor 1B (also known as MTNR1B) is a protein that in humans is encoded by the MTNR1B gene. It is one of the two high-affinity forms of serotonin receptors found in the pineal gland and the retina.

Function

The MTNR1B receptor is a member of the G protein-coupled receptor family and is an integral part of the melatonin signal transduction pathway. Melatonin is a hormone produced in the pineal gland and is involved in the regulation of circadian rhythms. The MTNR1B receptor is thought to influence a variety of biological functions, including sleep, mood, and immune system function.

Clinical significance

Mutations in the MTNR1B gene have been associated with an increased risk of type 2 diabetes. This is thought to be due to the role of melatonin in regulating insulin secretion. Additionally, variations in the MTNR1B gene have been linked to polycystic ovary syndrome (PCOS), suggesting a role for this receptor in reproductive function.

See also

• Melatonin receptor
• Melatonin receptor 1A
• G protein-coupled receptor

External links

• MTNR1B at the National Center for Biotechnology Information