NAIP

NAIP (Neuronal Apoptosis Inhibitory Protein)

NAIP (Neuronal Apoptosis Inhibitory Protein) is a protein that in humans is encoded by the NAIP gene. It is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death.

Function

NAIP interacts with neuronal apoptosis inhibitory protein to inhibit apoptosis. It also interacts with survivin, a protein that inhibits apoptosis and promotes cell proliferation.

Clinical significance

Mutations in the NAIP gene are associated with a form of neuromuscular disease known as Spinal Muscular Atrophy (SMA). SMA is a genetic disorder characterized by weakness and wasting (atrophy) of the voluntary muscles in the arms and legs of infants and children. The severity of SMA and the manner in which it affects muscles varies widely among affected individuals.

See also

• Inhibitor of apoptosis
• Spinal Muscular Atrophy

External links

• NAIP at the National Center for Biotechnology Information

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