Nephrogenic Systemic Fibrosis
Nephrogenic Systemic Fibrosis (pronounced: nef-ro-jen-ic sis-tem-ic fi-bro-sis) is a rare medical condition that affects the skin and internal organs. It is primarily associated with patients who have advanced Kidney Disease or Kidney Failure, and have been exposed to gadolinium-based contrast agents used in Magnetic Resonance Imaging (MRI).
Etymology
The term "Nephrogenic" is derived from the Greek words "nephros" meaning kidney and "genesis" meaning origin. "Systemic" refers to something that is spread throughout the body, and "Fibrosis" refers to the thickening and scarring of connective tissue, usually as a result of injury.
Symptoms
The symptoms of Nephrogenic Systemic Fibrosis can vary greatly from person to person. However, common symptoms include:
- Thickening and darkening of the skin
- Skin that feels tight or hard
- Joint contractures
- Muscle weakness
- Reduced range of motion
Causes
Nephrogenic Systemic Fibrosis is primarily caused by exposure to gadolinium-based contrast agents used in MRI scans in patients with advanced kidney disease or kidney failure. The exact mechanism of how this exposure leads to the condition is not fully understood.
Treatment
There is currently no cure for Nephrogenic Systemic Fibrosis. Treatment is focused on managing symptoms and preventing further progression of the disease. This may include physical therapy, medication to manage pain and inflammation, and dialysis in severe cases.
Related Terms
External links
- Medical encyclopedia article on Nephrogenic Systemic Fibrosis
- Wikipedia's article - Nephrogenic Systemic Fibrosis
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