Pamiparib

A PARP inhibitor used in cancer treatment

Pamiparib
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Pamiparib is a PARP inhibitor that is used in the treatment of certain types of cancer. It is particularly utilized in the management of ovarian cancer and other malignancies associated with BRCA mutations.

Mechanism of Action

Pamiparib functions by inhibiting the enzyme poly ADP ribose polymerase (PARP). PARP plays a critical role in the repair of single-strand DNA breaks through the base excision repair pathway. By inhibiting PARP, pamiparib prevents the repair of single-strand breaks, leading to the accumulation of double-strand breaks during DNA replication. In cells with deficient homologous recombination repair mechanisms, such as those with BRCA1 or BRCA2 mutations, this accumulation of DNA damage can lead to cell death.

Clinical Use

Pamiparib is primarily used in the treatment of ovarian cancer, particularly in patients with BRCA mutations. It is also being investigated for use in other types of cancer, including breast cancer and prostate cancer. The drug is administered orally and is often used in patients who have already undergone other forms of chemotherapy.

Side Effects

Common side effects of pamiparib include nausea, fatigue, anemia, and thrombocytopenia. More serious side effects can include myelodysplastic syndrome and acute myeloid leukemia, although these are less common. Patients undergoing treatment with pamiparib require regular monitoring of their blood counts and overall health.

Development and Approval

Pamiparib was developed by BeiGene, a biotechnology company. It has undergone various clinical trials to assess its efficacy and safety in treating different types of cancer. The drug has been approved for use in several countries and continues to be the subject of ongoing research.

Related pages

• Ovarian cancer
• BRCA mutation
• PARP inhibitor
• DNA repair