Plakoglobin
Plakoglobin
Plakoglobin (pronounced pla-ko-glo-bin), also known as γ-catenin (pronounced gamma-catenin), is a protein that in humans is encoded by the JUP gene.
Etymology
The term "plakoglobin" is derived from the Greek words "plako" meaning plate and "globin" meaning globe, referring to the protein's role in cell adhesion. The alternative name, γ-catenin, is derived from the Greek letter gamma (γ), used in science as a prefix to denote a third entity in a series, and "catenin", a term used to describe a family of proteins involved in the regulation of cellular adhesion.
Function
Plakoglobin is a major cytoplasmic protein which is the only known common component of the two types of adhesive junctions found in epithelial cells, desmosomes and adherens junctions. It is believed to have a crucial role in the assembly and stability of these junctions.
Related Terms
- Desmosomes: A type of cell junction in which cells are attached to each other.
- Adherens junctions: A cell junction whose cytoplasmic face is linked to the actin cytoskeleton.
- Catenin: A family of proteins that play an important role in the regulation of cellular adhesion.
- JUP gene: The gene that encodes the plakoglobin protein in humans.
See Also
External links
- Medical encyclopedia article on Plakoglobin
- Wikipedia's article - Plakoglobin
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