Pyroglutamylated RFamide peptide receptor

Pyroglutamylated RFamide Peptide Receptor

The Pyroglutamylated RFamide Peptide Receptor (QRFPR) is a G protein-coupled receptor (GPCR) that is activated by the neuropeptide QRFP. This receptor is involved in various physiological processes, including the regulation of appetite, metabolism, and cardiovascular function.

Structure

QRFPR is a member of the G protein-coupled receptor family, which is characterized by seven transmembrane domains. These receptors are integral membrane proteins that transmit signals from extracellular ligands to intracellular G proteins.

Function

The primary function of the QRFPR is to bind the neuropeptide QRFP, also known as 26RFa, which is involved in the regulation of energy homeostasis and feeding behavior. Activation of QRFPR by QRFP leads to various downstream effects, including the modulation of hormone secretion and neuronal activity.

Expression

QRFPR is expressed in several tissues, including the brain, heart, and adipose tissue. Its expression in the hypothalamus is particularly important for its role in regulating appetite and energy balance.

Clinical Significance

Alterations in QRFPR signaling have been implicated in obesity and metabolic disorders. Understanding the role of QRFPR in these conditions could lead to the development of new therapeutic strategies for managing obesity and related metabolic diseases.

See Also

• G protein-coupled receptor
• Neuropeptide
• QRFP
• Energy homeostasis

External Links

• Pyroglutamylated RFamide Peptide Receptor on WikiMD

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