RAMP2

RAMP2 or Receptor Activity Modifying Protein 2 is a protein that in humans is encoded by the RAMP2 gene. It is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus.

Function

RAMP2, along with RAMP1 and RAMP3, are necessary for transport of the calcitonin gene-related peptide receptor component protein to the cell surface. RAMP2 is able to interact with two different proteins: calcitonin-receptor-like receptor and calcitonin receptor to create two different receptors with different functions.

Clinical Significance

Mutations in the RAMP2 gene have been associated with pulmonary hypertension. Studies have shown that RAMP2 plays a crucial role in maintaining vascular integrity. It is also involved in the pathogenesis of various cardiovascular diseases, including hypertension, heart failure, and atherosclerosis.

Research

Research on RAMP2 is ongoing, with studies focusing on its role in cardiovascular diseases and potential as a therapeutic target.

See Also

• RAMP1
• RAMP3
• Calcitonin gene-related peptide
• Calcitonin receptor

References

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