Roxadustat
Roxadustat
Roxadustat (pronunciation: rox-a-DUS-tat) is a medication used for the treatment of anemia associated with chronic kidney disease (CKD). It is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis by increasing endogenous production of erythropoietin, improving iron regulation, and reducing hepcidin.
Etymology
The name "Roxadustat" is derived from its chemical structure. The prefix "Roxa-" is derived from the Latin word "Rox", meaning "light", and the suffix "-dustat" is derived from the Latin word "dustat", meaning "to give". This is in reference to the drug's mechanism of action, which involves the stimulation of erythropoiesis (the production of red blood cells) in response to hypoxia, or low oxygen levels.
Usage
Roxadustat is used for the treatment of anemia in patients with chronic kidney disease, both in patients who are and are not on dialysis. It is administered orally, typically three times a week.
Mechanism of Action
Roxadustat works by inhibiting the enzyme prolyl hydroxylase, which is involved in the degradation of hypoxia-inducible factors (HIFs). By inhibiting this enzyme, Roxadustat allows for the stabilization and accumulation of HIFs, which then bind to hypoxia response elements in the DNA and stimulate the production of erythropoietin, a hormone that promotes the production of red blood cells.
Side Effects
Common side effects of Roxadustat include hypertension, headache, diarrhea, and nausea. Serious side effects may include thrombosis and heart failure.
Related Terms
External links
- Medical encyclopedia article on Roxadustat
- Wikipedia's article - Roxadustat
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