SCF

SCF (Stem Cell Factor) is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a membrane-bound and a soluble form. The membrane-bound form is a result of specific proteolytic cleavage and has been shown to be biologically active, promoting the survival and proliferation of hematopoietic stem cells, while the soluble form can be produced by alternative splicing or proteolytic cleavage.

Function

SCF plays a crucial role in the maintenance of hematopoietic stem cells, and in particular, the survival and proliferation of myeloid, erythroid, and lymphoid progenitors. It is also essential for the survival and function of mast cells, which are involved in allergic responses.

Clinical significance

Mutations in the gene encoding SCF or in the c-Kit receptor can lead to a variety of disorders. For example, mutations in the c-Kit receptor are associated with gastrointestinal stromal tumors, while mutations in the SCF gene can lead to piebaldism, a disorder characterized by patches of unpigmented skin and hair.

See also

• Cytokine
• Hematopoietic stem cell
• Mast cell
• Gastrointestinal stromal tumor
• Piebaldism

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