SH-SY5Y

From WikiMD's medical encyclopedia

SH-SY5Y is a human derived neuroblastoma cell line. This cell line is commonly used in scientific research for the study of neuronal function and differentiation. It is also used in the study of Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases.

History

The SH-SY5Y cell line was first established in the 1970s. It was derived from a bone marrow biopsy taken from a four-year-old female with neuroblastoma. The cell line has been used extensively in research since its establishment.

Characteristics

SH-SY5Y cells are adherent cells that grow in a monolayer. They have a doubling time of approximately 24 to 48 hours. The cells are capable of differentiating into neuron-like cells when treated with agents such as retinoic acid or brain-derived neurotrophic factor (BDNF).

Use in Research

SH-SY5Y cells are commonly used in research due to their ability to differentiate into neuron-like cells. This makes them a useful model for studying neuronal function and differentiation. They are also used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Alzheimer's Disease

In Alzheimer's disease research, SH-SY5Y cells are often used to study the effects of amyloid beta peptides on neuronal cells. They are also used to investigate the role of various genes and proteins in the disease process.

Parkinson's Disease

In Parkinson's disease research, SH-SY5Y cells are used to study the effects of alpha-synuclein aggregation on neuronal cells. They are also used to investigate the role of various genes and proteins in the disease process.

See Also

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SH-SY5Y

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    SH-SY5Y

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Contributors: Prab R. Tumpati, MD