STAT4

STAT4 is a protein that in humans is encoded by the STAT4 gene. It is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form transcription factors that translocate to the nucleus, where they activate gene transcription.

Function

STAT4 is a transcription factor that transmits signals induced by interleukin 12, interleukin 23, and type I interferons. It is involved in the development of T helper cells and can influence the differentiation of T cells and natural killer cells.

Clinical significance

Variations in the STAT4 gene have been associated with systemic lupus erythematosus and rheumatoid arthritis.

Interactions

STAT4 has been shown to interact with STAT1 and STAT6.

See also

• STAT protein
• Signal transducer and activator of transcription

External links

• STAT4 at the National Center for Biotechnology Information