Signal peptide

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Signal peptide

Signal peptide (pronunciation: /ˈsɪɡnəl ˈpiːptaɪd/), also known as leader peptide or presequence, is a short (3-60 amino acids long) peptide chain that directs the post-translational transport of a protein.

Etymology

The term "signal peptide" was first used in 1975 by Günter Blobel and David D. Sabatini, who proposed the "signal hypothesis" to explain the translocation of proteins across the endoplasmic reticulum membrane.

Function

Signal peptides function as a postal code for proteins, directing them to their correct locations within the cell. They are usually found at the N-terminus of the protein sequence and are cleaved off by a signal peptidase once the protein reaches its destination.

Related terms

See also

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