SmeT
SmeT
SmeT (pronounced: /smɛt/) is a medical term that refers to a specific protein that plays a crucial role in the resistance of certain bacteria to antibiotics.
Etymology
The term "SmeT" is derived from the abbreviation of "Smell Metabolite Transporter". It is named so due to its function in the transportation of metabolites in bacteria.
Function
SmeT is a repressor protein that is part of the SmeDEF efflux pump system in Stenotrophomonas maltophilia, a multi-drug resistant bacterium. This protein binds to the promoter region of the SmeDEF operon, inhibiting the transcription of the SmeDEF efflux pump genes and thus reducing the bacterium's resistance to antibiotics.
Related Terms
- SmeDEF: An efflux pump system in Stenotrophomonas maltophilia that confers resistance to a wide range of antibiotics.
- Stenotrophomonas maltophilia: A multi-drug resistant bacterium in which the SmeT protein is found.
- Efflux pump: A protein that transports antibiotics out of bacterial cells, contributing to antibiotic resistance.
- Operon: A functioning unit of genomic DNA containing a cluster of genes under the control of a single promoter.
See Also
External links
- Medical encyclopedia article on SmeT
- Wikipedia's article - SmeT
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