Somatostatin receptor 2

Somatostatin receptor 2 (SSTR2) is a protein that in humans is encoded by the SSTR2 gene. It is one of the five somatostatin receptors.

Function

Somatostatin receptor 2 is a G protein-coupled receptor that inhibits the release of somatotropin, also known as growth hormone. It is expressed in the pancreas, kidney, prostate, and adrenal gland, among other tissues.

Clinical significance

Mutations in the SSTR2 gene have been associated with neuroendocrine tumors. The receptor is also a target for octreotide, a drug used to treat acromegaly and neuroendocrine tumors.

Structure

The SSTR2 gene is located on the long arm of chromosome 17 (17q24). The protein encoded by this gene is a 369 amino acid protein with seven transmembrane domains, characteristic of G protein-coupled receptors.

Ligands

Several ligands have been developed for SSTR2, including octreotide, lanreotide, and pasireotide. These drugs are used to treat conditions such as acromegaly and neuroendocrine tumors.

See also

• Somatostatin receptor
• G protein-coupled receptor
• Octreotide
• Lanreotide
• Pasireotide