Sphingosine

Sphingosine is an amino alcohol that forms a fundamental part of sphingolipids, a class of lipids that are crucial components of cell membranes. It is also involved in various signaling pathways.

Structure and Properties

Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain. The structure of sphingosine is distinctive due to the presence of an amino group (NH2) and two hydroxyl groups (OH). The amino group is attached to the second carbon atom, while the hydroxyl groups are attached to the first and third carbon atoms.

Biological Role

Sphingosine plays a crucial role in the formation of sphingolipids, which are essential components of cell membranes. These lipids are involved in various cellular processes, including cell signaling, cell recognition, and cell adhesion. Sphingosine can be phosphorylated to form sphingosine-1-phosphate, a potent signaling molecule that regulates diverse cellular processes.

Health Implications

Alterations in sphingosine metabolism have been linked to various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For instance, elevated levels of sphingosine-1-phosphate have been associated with the progression of cancer and inflammatory diseases.

See Also

• Sphingolipid
• Cell membrane
• Amino alcohol

References

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  Sphingosine structure

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  Sphingosine synthesis

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  Sphingolipidoses

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  Sphingolipids general structures