Spiroxatrine
Chemical compound
| Spiroxatrine | |
|---|---|
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| CAS Number | 1054-88-0 |
| PubChem | 5358 |
| DrugBank | |
| ChemSpider | 5164 |
| KEGG | D06177 |
Spiroxatrine is a chemical compound that acts as a serotonin receptor antagonist and dopamine receptor antagonist. It is primarily used in scientific research to study the effects of these neurotransmitters in the central nervous system.
Pharmacology
Spiroxatrine exhibits high affinity for the 5-HT1A receptor, where it acts as an antagonist. It also shows affinity for the dopamine D2 receptor, making it a useful tool in the study of dopaminergic and serotonergic systems. The compound's dual action on these receptors makes it valuable in research related to psychiatric disorders such as schizophrenia and depression.
Mechanism of Action
As a 5-HT1A receptor antagonist, spiroxatrine inhibits the action of serotonin at this receptor site, which can influence mood, anxiety, and other functions regulated by serotonin. Its action on the dopamine D2 receptor involves blocking the effects of dopamine, which is crucial in the study of disorders like Parkinson's disease and schizophrenia.
Research Applications
Spiroxatrine is used extensively in neuropharmacology to understand the role of serotonin and dopamine in the brain. It helps in elucidating the pathways and mechanisms involved in various neuropsychiatric disorders. Studies involving spiroxatrine contribute to the development of new therapeutic agents targeting these neurotransmitter systems.
Safety and Handling
As with many research chemicals, proper safety protocols must be followed when handling spiroxatrine. It should be used in a controlled laboratory environment, and appropriate personal protective equipment (PPE) should be worn to avoid exposure.
See also
References
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