TAB1
TAB1 or TGF-beta activated kinase 1/MAP3K7 binding protein 1 is a protein that in humans is encoded by the TAB1 gene. TAB1 is a critical component of the TGF-beta signaling pathway. It binds to TAK1 and aids in its activation upon the stimulation of TGF-beta.
Function[edit]
TAB1 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of NF-kappaB and JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB2; this complex is required for the activation of MAP3K7 following engagement of the Toll-like receptors. MAP3K7 activated by the binding of TAB1 to TRAF6, which is required for K63-linked polyubiquitination of TRAF6, and the subsequent activation of IKK and NF-kappaB.
Clinical significance[edit]
Mutations in TAB1 have been associated with congenital heart defects.
Interactions[edit]
TAB1 has been shown to interact with:
References[edit]
External links[edit]
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See also[edit]
- TGF-beta
- TAK1
- TRAF6
- NF-kappaB
- JNK
- Toll-like receptors
- Polyubiquitination
- Congenital heart defects
- Protein-protein interaction
- MAP3K7
- CSNK2A1
- CSNK2A2
- CSNK2B
- National Center for Biotechnology Information
