TAP1

TAP1 (Transporter 1, ATP-binding cassette sub-family B) is a protein that in humans is encoded by the TAP1 gene. It is a member of the ABC transporter family, which are integral membrane proteins that utilize ATP to drive the transport of various molecules across the cell membrane.

Function

TAP1 is involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It also interacts with the viral proteins of certain viruses, preventing the transport of the antigenic peptides into the endoplasmic reticulum.

Clinical significance

Mutations in the TAP1 gene can lead to bare lymphocyte syndrome, a type of MHC class I deficiency. This can result in a variety of immune disorders, including increased susceptibility to viral infections.

Structure

The TAP1 protein is composed of two subunits, each of which has six transmembrane domains. The protein also contains an ATP-binding domain, which is responsible for the energy-dependent transport of antigens.

Interactions

TAP1 has been shown to interact with:

• TAP2
• Tapasin
• Calreticulin
• ERp57

See also

• ATP-binding cassette transporter
• MHC class I

External links

• TAP1 at the US National Library of Medicine Medical Subject Headings (MeSH)