ZD6474
ZD6474
ZD6474 (pronounced Zee-Dee-Six-Four-Seven-Four), also known as Vandetanib (pronounced Van-de-ta-nib), is a small molecule pharmaceutical drug designed to inhibit the receptor tyrosine kinases of epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and RET proto-oncogene (RET). It is primarily used in the treatment of certain types of thyroid cancer and non-small cell lung cancer.
Etymology
The name "ZD6474" is a code name given by the drug's developer, AstraZeneca. The "ZD" prefix is commonly used in AstraZeneca's investigational compounds, while the numbers "6474" are arbitrary and do not hold any specific meaning. The generic name "Vandetanib" is derived from the drug's mechanism of action, with "van" referring to VEGFR and "de" referring to EGFR, the two main targets of the drug.
Mechanism of Action
ZD6474 works by inhibiting the activity of certain protein kinases, specifically EGFR, VEGFR, and RET. These kinases are involved in the growth and spread of cancer cells. By inhibiting these kinases, ZD6474 can slow down or stop the growth of cancer cells.
Related Terms
- AstraZeneca: The pharmaceutical company that developed ZD6474.
- Epidermal growth factor receptor (EGFR): A protein that ZD6474 targets to inhibit cancer cell growth.
- Vascular endothelial growth factor receptor (VEGFR): Another protein that ZD6474 targets to inhibit cancer cell growth.
- RET proto-oncogene (RET): A gene that can cause cancer when it is mutated. ZD6474 targets the protein produced by this gene.
- Thyroid cancer: A type of cancer that ZD6474 is used to treat.
- Non-small cell lung cancer (NSCLC): Another type of cancer that ZD6474 is used to treat.
External links
- Medical encyclopedia article on ZD6474
- Wikipedia's article - ZD6474
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