ZNF24

ZNF24 (Zinc Finger Protein 24) is a protein that in humans is encoded by the ZNF24 gene. This protein is a member of the Krüppel family of C2H2-type zinc finger proteins, which are involved in a variety of biological processes.

Function

ZNF24 is a transcription factor that can bind to DNA and regulate the expression of other genes. It is involved in various cellular processes such as cell growth, differentiation, and apoptosis. The protein contains a Krüppel-associated box (KRAB) domain, which is a potent transcriptional repressor.

Clinical significance

Mutations in the ZNF24 gene have been associated with various diseases. For example, a study found that a mutation in this gene was associated with congenital heart disease. Another study suggested that ZNF24 might play a role in the progression of breast cancer.

Structure

The ZNF24 protein is composed of 18 zinc finger domains, which are DNA-binding domains. Each zinc finger domain consists of a sequence of amino acids that wraps around a zinc ion, forming a finger-like structure.

See also

• Zinc finger
• Transcription factor
• Gene expression
• Congenital heart disease
• Breast cancer

References

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