ZNF350

ZNF350 (also known as Zinc Finger Protein 350) is a protein that in humans is encoded by the ZNF350 gene. This protein is a member of the zinc finger family of proteins, which are characterized by the presence of zinc finger domains. These domains are known to bind to DNA, RNA, protein and/or lipid substrates.

Function

ZNF350 is a transcription factor that plays a crucial role in the regulation of gene expression. It binds to specific DNA sequences in the promoter regions of target genes and modulates their expression. This protein is involved in various cellular processes, including cell differentiation, cell growth, apoptosis, and response to DNA damage.

Clinical Significance

Mutations in the ZNF350 gene have been associated with various diseases. For instance, it has been implicated in breast cancer, where it acts as a tumor suppressor by inhibiting cell growth and promoting apoptosis. Moreover, it has been suggested that ZNF350 may play a role in other types of cancer, such as ovarian cancer and lung cancer.

Structure

The ZNF350 protein consists of several zinc finger domains, which are characterized by the coordination of one or more zinc ions in order to stabilize the fold. These domains enable the protein to interact with various biological molecules, thereby influencing numerous cellular processes.

See Also

• Zinc finger
• Transcription factor
• Gene expression
• Breast cancer
• Tumor suppressor

References

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