Desmoplasia
Desmoplasia
Desmoplasia (pronunciation: /dɛzməˈpleɪziə/) is a term used in pathology to refer to the growth of fibrous or connective tissue. It is often used to describe the fibrotic reaction brought about by certain neoplasms, particularly carcinoma.
Etymology
The term "desmoplasia" originates from the Greek words "desmos" which means "bond" and "plasis" which means "formation". Thus, the term essentially refers to the formation of bonds or connections, which is indicative of the process that occurs in the body during desmoplasia.
Definition
Desmoplasia is a process that occurs in response to injury, inflammation, or in the presence of neoplasms. It involves the proliferation of fibroblasts, which are a type of cell that produces collagen and other extracellular matrix proteins. This results in the formation of dense fibrous tissue around the area of injury or neoplasm.
Related Terms
- Fibrosis: This is a process similar to desmoplasia, involving the proliferation of fibrous connective tissue. However, fibrosis can occur in response to a wider range of stimuli and can affect various organs and tissues in the body.
- Neoplasm: This is an abnormal growth of tissue, which can be benign or malignant. Desmoplasia is often associated with malignant neoplasms, particularly carcinomas.
- Carcinoma: This is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. Desmoplasia is a common reaction to the presence of carcinomas.
- Fibroblast: This is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals.
External links
- Medical encyclopedia article on Desmoplasia
- Wikipedia's article - Desmoplasia
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